Herein, we report a new synthetic strategy for 2-(pyridin-2-yl)phenols and 2-(pyridin-2-yl)anilines catalyzed by a Pd/C–ethylene system. The starting materials, 2-(pyridin-2-yl)cyclohexan-1-ones, can be easily prepared by the reaction of substituted pyridine N-oxide and cyclohexanones. The most useful feature of this method is that both 2-(pyridin-2-yl)phenols and 2-(pyridin-2-yl)anilines are easily synthesized independently using the same compound as a starting material, simply by adding or not adding a nitrogen source.
No takes yet. Share an insight, caveat, or question.
Miki et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: