Synthetic strategy demonstrates effective production of nitrones from nitroalkenes using hydrogenation.
A practical and simple synthetic strategy for the synthesis of nitrones have been developed. Hydrogenation of 2-(2-nitro-1-phenylethyl)cyclohexanone by Pd/C afforded the corresponding nitrones in good to high and in high diastereoselectively. The starting materials, 2-(2-nitro-1-phenylethyl)cyclohexanones were easily prepared by the reaction of substituted cyclohexanones and nitroalkenes in the presence of 10 mol% of pyrrolidine.
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Li et al. (2025) studied this question.
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