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Lactic acid bacteria (LAB) are considered a significant member of the human and animal intestinal microbiota due to their effects on host health, such as regulating the balance of the human and animal gastrointestinal microbiota. Thus, microecological balance can be maintained, and microbial infections can be prevented. In addition, LAB are used in bioprotective cultures to prevent spoilage and pathogenic microorganisms in the food industry. The therapeutic agents possessed by LAB include metabolites containing antibacterial, antifungal, antiviral, antioxidant, anticancer, immunomodulatory, and anti-inflammatory properties. Lactobacillus and Lactococcus may have potential therapeutic properties. In conclusion, LAB are commonly used in several industries, including food, clinical, agricultural, and animal husbandry. This Review aims to summarize the therapeutic properties of LAB, including recombinant and antimicrobial. LAB metabolites with therapeutic properties may be an alternative strategy to antibiotics in controlling infections, or these metabolites may be used synergistically with antibiotics. Additionally, this Review presents the advantages of LAB's therapeutic properties.
Turgut Kılıç (Tue,) studied this question.