What question did this study set out to answer?

To comprehensively review the antivirulence mechanisms of probiotic lactic acid bacteria against diverse pathogens and assess their potential clinical applications.

March 26, 2025Beneficial Microbes

Antivirulence effects of lactic acid bacteria: pioneering new probiotic applications

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To comprehensively review the antivirulence mechanisms of probiotic lactic acid bacteria against diverse pathogens and assess their potential clinical applications.
Synthesized literature on the biological and functional mechanisms of probiotic lactic acid bacteria.
Evaluated bacterial signaling interference, focusing on quorum sensing and two-component regulatory systems.
Categorized pathogen-directed actions, including anti-adhesion, biofilm disruption, toxin neutralization, and enzyme inhibition.
Lactic acid bacteria produce antivirulence molecules that neutralize pathogen threats without inhibiting growth, substantially lowering selective pressure for antimicrobial resistance.
Probiotic compounds disrupt bacterial communication pathways, including two-component systems and quorum sensing, to repress virulence gene expression.
Strains demonstrate broad-spectrum protective effects by impairing pathogen adhesion, dismantling biofilms, and neutralizing extracellular toxins and enzymes.

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Implication

Narrative review uncovers antivirulence pathways of lactic acid bacteria against microbial pathogens, highlighting alternative strategies to counteract antibiotic resistance.

Cite This Study

Sabino et al. (2025) studied this question.

synapsesocial.com/papers/6a83bc1ef4298de60b3c280c https://doi.org/10.1163/18762891-bja00063

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Implication

Narrative review uncovers antivirulence pathways of lactic acid bacteria against microbial pathogens, highlighting alternative strategies to counteract antibiotic resistance.

Antivirulence effects of lactic acid bacteria: pioneering new probiotic applications

Key Points

Discussion

Implication

Cite This Study

Antivirulence effects of lactic acid bacteria: pioneering new probiotic applications

Key Points

Discussion

Implication

Cite This Study

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