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April 1, 2024Clinical Gastroenterology and HepatologyOpen Access

Clinical Outcomes and Safety of Upper Endoscopy While on Glucagon-Like Peptide-1 Receptor Agonists

Stephen A. Firkins J. C. Yates Neehal Shukla Rajat Garg John J. Vargo Anthony Lembo

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Abstract

Glucose-like peptide-1-receptor agonists (GLP-1RAs) have become integral to the management of type 2 diabetes and obesity. GLP-1RAs work in part through delaying gastric emptying, raising concerns about retained gastric contents (RGC) during esophagogastroduodenoscopy (EGD).

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Firkins et al. (2024) studied this question.

synapsesocial.com/papers/68e70d94b6db6435876870fa https://doi.org/10.1016/j.cgh.2024.03.013

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Effects of Glucagon-like Peptide-1 Receptor Agonists on Upper Endoscopy in Diabetic and Non-Diabetic Patients2024 · 48 citations
2Is it necessary to stop glucagon-like peptide-1 receptor agonists prior to endoscopic procedure? A retrospective study2024 · 22 citations
3Risk of Aspiration Pneumonitis After Elective Esophagogastroduodenoscopy in Patients on Glucagon-Like Peptide-1 Receptor Agonists2024 · 12 citations
4Evaluating Glucagon-Like Peptide-1 Receptor Agonist Safety Before Upper Endoscopy: A Systematic Review and Meta-AnalysisMeta-Analysis · 2026
5Real-World Impact of GLP-1 Receptor Agonists on Endoscopic Patient Outcomes in an Ambulatory Setting: A Retrospective Study at a Large Tertiary Center2024 · 20 citations

More related papers

GLP-1 Receptor Agonists and Gastrointestinal Endoscopy: A Narrative Review of Risks, Management Strategies, and the Need for Clinical Consensus2025
Glucagon-like Peptide-1 Receptor Agonists and Upper Gastrointestinal Endoscopy: A Narrative Review of Residual Gastric Contents Aspiration Risk and Periprocedural Management2026
Impact of Glucagon‐Like Peptide‐1 Receptor Agonists on Retained Gastric Contents During Esophagogastroduodenoscopy: A Propensity Score‐Matched Study2025

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