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October 9, 2025The Egyptian Journal of Medical Microbiology

Study of T cell Immunoreceptor with Ig and Immunoreceptor Tyrosine-Based Inhibitory Motif Domains Marker in Iraqi Patients with DM Type-1

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Authors

THTiba M. HadiMiddle Technical UniversityFRFarhan Abood RisanMiddle Technical UniversityMAMontaha Abdulkareem Al-SaffarMiddle Technical University

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Overview

Case-control study shows elevated TIGIT levels in T1DM patients, indicating potential as an immunological biomarker.

Key Points

  • TIGIT levels are significantly higher in T1DM patients compared to healthy controls, highlighting its relevance in diabetes research.
  • HbA1c levels were significantly elevated in T1DM patients at 10.47%, indicating poor glycemic control, versus 4.81% in controls.
  • A case-control study analyzed blood samples from 100 T1DM patients and 50 healthy individuals looking at multiple biomarkers.
  • TIGIT elevation occurs independently of glycemic control and β-cell function, suggesting it may serve as a reliable biomarker.

Cite This Study

Hadi et al. (2025) studied this question.

synapsesocial.com/papers/68e70db290569dd607ee63f4https://doi.org/10.21608/ejmm.2025.422370.1863
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced TIGIT Expression on T Cells Links Hyperglycemia to Immune Dysregulation in Type 1 Diabetes2026
  2. 2The protective role of <scp>TIGIT</scp>+ B cells in attenuating type 1 diabetes progression2025
  3. 3TIGIT acts as an immune checkpoint upon inhibition of PD1 signaling in autoimmune diabetes2024 · 10 citations
  4. 4Integrated Bioinformatics Analysis Revealed Immune Checkpoint Genes Relevant to Type 2 Diabetes2024 · 2 citations
  5. 5Evaluation of ANGPTL8 and TGF-β1 Levels in Type 1 Diabetes Patients: Association with Gender and Age2025