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The research investigates how checkpoint inhibitor expression in T cells affects glucose metabolism in type 1 diabetes.

January 22, 2026CellsOpen Access

Reduced TIGIT Expression on T Cells Links Hyperglycemia to Immune Dysregulation in Type 1 Diabetes

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Reveals that hyperglycemia reduces T cell regulation in type 1 diabetes, suggesting immune challenges.

The research investigates how checkpoint inhibitor expression in T cells affects glucose metabolism in type 1 diabetes.
Analyzed T cell subsets using multicolor flow cytometry.
Conducted spectrophotometric analysis for metabolic assessments.
Performed bead-based multiplex assays for further investigation.
TIGIT+ Tregs and TIGIT+ Tconvs were significantly lower in T1D patients compared to healthy controls.
Hyperglycemia decreased percentages of TIGIT+ Tregs and Tconvs in vitro.
Reduced percentages of these T cell subsets correlated with lower glucose uptake.

Tomaszewicz et al. (2026) studied this question.

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