Comparative Analysis of Weekly Cisplatin Versus Weekly Paclitaxel with Radiotherapy in Locally Advanced Head and Neck Cancer

Introduction: Globally head and neck cancer is 7th most common cancer with more than 66,000 new cases and about 50% deaths annually.In India, head and neck cancer incidence is higher as compared to western world due to risk factors like oral tobacco, betel nut chewing, Pan masala, poor oral hygiene, and smoking habits. Material and Method:We included 120 Patients.All patients were treated with radical intent.All the patients were histologically proven advanced head and neck carcinoma from stage II, III & IV in 8-month duration from -Sept 22 to April 23, patients were divided into two arms. Conclusion:Weekly paclitaxel with the dose of 75 mg/nm2 with radiotherapy can be considered as a promising and feasible alternative for the treatment of locally advanced Head and Neck Carcinoma.Haematological toxicities mucositis and skin reaction was higher but manageable.xerostomia and the loss of taste was reported more in cisplatin arm.