Supplementary Figure S6 from Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer

Noah Earland; Nicholas P. Semenkovich; Ricardo J. Ramirez; Sophie P. Gerndt; Peter K. Harris; Zhuosheng Gu; Andrew I. Hearn; Matthew Inkman; Jeffrey J. Szymanski; Damion Whitfield; Benjamin M. Wahle; Zhongping Xu; Kevin Chen; Irfan Alahi; Gabris Ni; Andrew Chen; Wendy Winckler; Jin Zhang; Aadel A. Chaudhuri; Jose P. Zevallos

doi:10.1158/1078-0432.25515786

Key Points

Recurrence stratification in HPV-associated oropharyngeal cancer correlates with postoperative detection of lymph cf-HPV and plasma cf-HPV alongside high-risk pathology features.
Postoperative assessment tracks patient recurrence trajectories by evaluating residual tumor biomarkers in lymphatic fluid alongside circulating plasma cf-HPV across risk groups.
Supports postoperative surveillance by demonstrating that lymphatic fluid sampling may enable sensitive minimal residual disease detection alongside standard high-risk pathology.

Implication

Postoperative analysis demonstrates recurrence stratification via lymph and plasma cf-HPV in HPV-positive oropharyngeal cancer, highlighting biomarkers for minimal residual disease.

Abstract

HPV (+) OPSCC recurrences stratified by postoperative lymph cf-HPV detection, plasma cf-HPV detection, or high-risk pathology.

Discussion

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Cite This Study

Earland et al. (2024) studied this question.

synapsesocial.com/papers/68e712c7b6db64358768bc64 https://doi.org/10.1158/1078-0432.25515786

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Supplementary Figure S6 from Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S6 from Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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