Supplementary Figure S2 from Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer

Noah Earland; Nicholas P. Semenkovich; Ricardo J. Ramirez; Sophie P. Gerndt; Peter K. Harris; Zhuosheng Gu; Andrew I. Hearn; Matthew Inkman; Jeffrey J. Szymanski; Damion Whitfield; Benjamin M. Wahle; Zhongping Xu; Kevin Chen; Irfan Alahi; Gabris Ni; Andrew Chen; Wendy Winckler; Jin Zhang; Aadel A. Chaudhuri; Jose P. Zevallos

doi:10.1158/1078-0432.25515798

Key Points

Cell-free HPV measurement in lymphatic fluid remains unaffected by blood contamination, ensuring accurate evaluation of postoperative minimal residual disease.
Analysis confirms stable cf-HPV measurement across surgical drainage fluid samples, demonstrating that blood contamination does not compromise diagnostic yield.
These findings support reliable MRD detection in HPV-associated oropharyngeal cancer, confirming that postoperative lymphatic fluid sampling remains clinically robust.

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Implication

Postoperative analysis demonstrates stable lymph cf-HPV measurement despite blood contamination in oropharyngeal cancer, indicating reliable residual disease monitoring.

Abstract

Blood contamination does not significantly impact lymph cf-HPV measurement.

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Cite This Study

Earland et al. (2024) studied this question.

synapsesocial.com/papers/68e712c7b6db64358768bc67 https://doi.org/10.1158/1078-0432.25515798

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Supplementary Figure S2 from Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

Supplementary Figure S2 from Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer

Key Points

No abstract yet

Implication

Abstract

Discussion

Cite This Study

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