WCN24-1285 Interplay of OSBPL7 and HIF-1α in Hyperoxia-Induced Podocyte Dysfunction

Preterm infants are increasingly susceptible to renal dysfunction, which has been correlated with podocyte derangement. Hyperoxia has been demonstrated to damage podocyte structure and function. The molecular pathways contributing to this phenomenon, particularly those involving Oxysterol-Binding Protein Like 7 (OSBPL7) and Hypoxia-Inducible Factor 1alpha (HIF-1α), remain elusive. This study aims to unravel these molecular underpinnings