Wcn24-2143 Neonatal Hyperoxia Exposure Leads to Developmental Programming of Adult Cardiovascular and Renal Disease

Premature infants are often exposed to hyperoxia. However, there is a lack of knowledge of the mechanistic underpinnings linking neonatal hyperoxia exposure and its contribution to cardio-renal dysfunction in adults born preterm. Our objective was to determine whether neonatal hyperoxia induces systemic vascular stiffness and cardio-renal dysfunction in adulthood.