WCN24-746 SUPPLEMENTATION WITH SULFORAPHANE INCREASES NRF2 mRNA EXPRESSION IN NONDIALYSIS CKD PATIENTS

Nuclear factor erythroid 2-related factor 2 (NRF2) is crucial in regulating cellular redox balance by increasing the expression of genes encoding antioxidant enzymes, such as heme oxygenase-1 (HO-1). However, patients with chronic kidney disease (CKD) have reduced NRF2 expression and overexpression of nuclear factor kappa B (NF-κB), a critical factor in pro-inflammatory responses. This imbalance contributes to CKD progression, cardiovascular outcomes, and high mortality rates. Sulforaphane (SFN), a bioactive compound found in cruciferous vegetables, is recognised as a natural NRF2 agonist and a potent anti-inflammatory agent.