Enhancing the hemocompatibility of dialysis membranes is crucial to reduce interactions between blood and the membrane, which can lead to blood activation. Inflammatory responses within the central nervous system may play a significant role in the development of mental disorders. This amplifies the heightened risk of psychological symptoms in dialysis patients, who experience increased inflammation due to ESRD. Additionally, depression is closely linked to inflammatory cytokines. This research aimed to: i) synthesize various new zwitterionic materials with different moieties and immobilized poly vinyl pyrrolidone (PVP) membranes; ii) assess the impact of these new membranes on inflammatory biomarkers and cytokines compared to the currently used membrane; and iii) correlate the levels of biomarkers with their potential impact on psychological symptoms.
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Abdelrasoul et al. (2024) studied this question.
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