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Chronic kidney disease of unknown origin occurs in young sugar cane workers in Central American countries and Mexico (Mesoamerican Nephropathy). Occupational heat stress from high physical workload in hot climate is a key etiology and pathophysiologic pathways need further investigation. We examined whether (repeated) episodes of subclinical rhabdomyolysis contribute to kidney injury and tested the validity of our observations in animal experiments.
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Madero et al. (2024) studied this question.
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