Wcn24-2379 Natural History of Primary Membranoproliferative Glomerulonephritis: How Does 1-Year Proteinuria Correlate With Long-Term Renal Outcome?

Membranoproliferative glomerulonephritis (MPGN) is a rare chronic nephropathy, affecting predominantly children and young adults and defined by a typical glomerular histopathological pattern of mesangial hypercellularity, endocapillary proliferation and duplication of the glomerular basement membrane. While clinical presentation and outcome are variable, the overall prognosis is poor, with progression to end-stage renal disease (ESRD) in about 40% of cases.