The Spontaneously Diabetic Torii (SDT) fatty rat is a relevant type 2 diabetic model to evaluate drugs targeting diabetic nephropathy. To further optimize the model for drug efficacy studies, we here tested the effects of unilateral nephrectomy and salt supplemented diet on kidney function and histology. Using quantitative image analysis, we also assessed podocyte foot process morphology and kidney fibrosis.
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BRIAND et al. (2024) studied this question.
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