In IgA nephropathy (IgAN), the detailed characteristics of nephritogenic IgA are still unclear. Recently, we have identified novel IgA type autoantibodies against mesangial autoantigen, βII-spectrin, in serum from patients with IgAN (Science Advances, 2023). Serum anti-βII-spectrin IgA (anti-SPTBN1 IgA) can bind to β2 Spectrin expressed on cell surface of mesangial cells; thus, we provided the novel pathogenesis of IgAN as a tissue-specific autoimmune disease rather than an immune-complex disease.
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Mori et al. (2024) studied this question.
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