Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer. Despite recent therapeutic advances, renal carcinoma invariably becomes resistant to systemic treatment. Tumor Necrosis Factor-Related Ligand (TRAIL)-induced apoptosis is a potential target of drugs; however, the majority of malign tumors are TRAIL-resistant. Moreover, TRAIL receptors, DR4 and DR5, may be associated with TRAIL-resistance since they can lose the function when internalizedthrough clathrin (CLTA). Apoptosis pathway induced by TRAIL involves specific molecules including APAF-1 and culin-3.
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Silva et al. (2024) studied this question.
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