Angiotensin II (Ang II) promotes the development and progression of podocytopathy. CD2-associated protein (CD2AP) in podocytes, anchoring slit diaphragm proteins to actin filaments of podocyte cytoskeleton, facilitates the nephrin-induced PI3-K/AKT signaling, which protects podocytes from apoptosis. AMP-activated protein kinase (AMPK), as a sensor of cellular energy status, has been known to play an important role in the pathophysiology of metabolic diseases, including diabetes, and its renal complications.
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Tae‐Sun Ha (2024) studied this question.
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