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March 25, 2026Kidney International ReportsOpen Access

Wcn26-5351 Procyanidin C1 Attenuates Kidney Tubular Senescence and Injury Instigated by the Diabetic Insults

Bohan Chen Pei Wang Xianhui Liang

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Key Points

The aim is to investigate how procyanidin C1 affects kidney tubular senescence and injury due to diabetic insults.
Analyzed the role of procyanidin C1 in mitigating kidney injuries in diabetic conditions.
Examined podocyte function and potential regenerative pathways, particularly the Notch2 signaling.
Utilized transcriptomic profiling to understand gene expression changes related to podocyte repair.
Procyanidin C1 effectively reduced indicators of kidney tubular senescence and injury.
The Notch2 pathway was identified as crucial for podocyte redifferentiation.
Inhibition of KDM1A led to enhanced histone modifications and increased podocyte population.

Implication

This research explores procyanidin C1's effects on kidney injury and aging, suggesting it may help improve podocyte function in diabetes.

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Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69c770418bbfbc51511e0760 https://doi.org/10.1016/j.ekir.2026.104626

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