We report an unusual case of isolated conjunctival histoplasmosis in a healthy immunocompetent patient. A 62-year-old male presented with a gradually progressing, painless, fleshy mass in both eyes for 2 months. On examination, a diffuse, raised, vascularized, and nontender mass was noted on the entire bulbar conjunctiva. On incisional biopsy, the histopathologic report confirmed a causative agent of Histoplasma capsulatum . He was then treated with topical itraconazole and intravenous amphotericin B, the lesion exhibited signs of regression. When confronted with an unusual conjunctival mass, it is imperative to do a detailed microbiological and histopathological work-up of a patient.
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