Adsorption and Thermodynamic Behaviour of Fluorographene with Melphalan Drug as Nanocarrier for Drug Delivery System

Fluorinated graphene (FG) has special physicochemical properties and a unique structure that make it very promising for use in biological fields.However, its strong hydrophobicity and chemical inertness severely restrict its further applications, and little research has been done on how to use FG as a drug nanocarrier.Within this research, the interaction studies of fluorinated graphene or fluorographene (FG) and melphalan (MEL) drug is studied through Density Functional Theory (DFT).The electronic properties and thermodynamic properties are analysed and tabulated using Gaussian 09 package with B3LYP functional and 6-311G basis set.Relying on the results, the FG-MEL complex adsorbs through physisorption process, reaction is exothermic and stable.Accordingly, the FG-MEL complex can act as a carrier in anticancer activity.