EFFECT OF VITAMIN D DEFICIENCY ON HYPERTROPHIC SCARRING: A meta-analysis.

Background: : Vitamin D is a fat soluable vitamin which is vital for different systems of the human body including endocrine and immune systems, endothelial function and wound healing.Patients and methods: This meta-analysis follows the PRISMA flow diagram. The study asses the relationship between vitamin D deficiency and hypertrophic scar incidence and determine vitamin D replacement therapy effect on hypertrophic scar width and scale in patients who have deficiency in vitamin D.Result: After the search and screening, one study was eligible for our meta-analysis. Results of meta-analysis shows that scar improvement occurred significantly with p value < 0.05 after vitamin D replacement in group (1) and this was represented by low level of Vancouver score but scar width did not change after treatment in both study groups.Conclusion: Our study may provide evidence that Vitamin D supplement may be used like an adjuvent treatment for hypertrophic scars as it reduce vascularity, pliability, pigmentation, and height of scars with little effect on scar width.