The purpose of this study was to determine the role of HYP-PDT and its cytotoxic and immunomodulatory efficacy in the treatment of oral cancer. SCC-25(oral squamous cell carcinoma) and HGF-1 (gingiva fibroblasts) cells were properly prepared and then treated with HYP-PDT. After HYP-PDT treatment, changes in the concentrations of sTNF-R1, sTNF-R2 and sCD30 were analyzed using Bioplex method. For SCC-25 cells: after HYP-PDT, there was a marked increase in the secretion of sTNF-R1 and sCD30 and no change in concentration of sTNF-R2. The applied HYP-PDT showed no effect on the secretion of sTNF-R1, sTNF-R2 and sCD30 by the HGF-1 cell line. HYP-PDT shows immunomodulatory potential in in vitro experiments.
No takes yet. Share an insight, caveat, or question.
Olek et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: