The purpose of this study was to determine the role of HYP-PDT and its cytotoxic and immunomodulatory efficacy in the treatment of colorectal cancer. SW480 and SW620 cells were properly prepared and then treated with HYP-PDT. After HYP-PDT treatment, changes in the concentrations of GM-CSF, MIF, VCAM-1, ICAM-1 and IL-2, IL-4, IL6 were analyzed using Bioplex method. For SW480 cells: after HYP-PDT, there was a marked decrease in the secretion of GM-CSF, MIF, VCAM-1 and ICAM-1. The applied HYP-PDT showed no effect on the secretion of IL-2, IL-4 and IL-6 by the cell lines. HYP-PDT shows immunomodulatory potential in in vitro experiments.
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Kawczyk‐Krupka et al. (2024) studied this question.
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