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April 1, 2024European PsychiatryOpen Access

Associations between psychiatric diagnoses in parents and psychiatric, behavioral, psychosocial outcomes in their offspring: a Swedish population-based register study

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Authors

MZMei ZhouInner Mongolia Agricultural UniversityCLChristine Takami LagebornKarolinska InstitutetASA. SjölanderKarolinska Institutet

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Implication

Matched cohort study reveals increased risk across diverse psychiatric and behavioral outcomes in offspring of affected parents, highlighting transdiagnostic intergenerational transmission.

Key Points

  • Offspring of parents with psychiatric conditions experience elevated risks across all 32 outcomes, showing widespread transdiagnostic vulnerability across life domains.
  • Matched cohort design tracking 3,286,293 individuals linked parental disorders to increased risks in offspring, with the hazard ratio reaching 8.91 for time-to-event events.
  • Highlights the pervasive intergenerational transmission of parental psychiatric illness, calling for care providers to evaluate comprehensive family history during treatment planning.

Cite This Study

Zhou et al. (2024) studied this question.

synapsesocial.com/papers/68e7170fb6db643587690946https://doi.org/10.1192/j.eurpsy.2024.202
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Associations between general and specific psychopathology factors in parents and psychiatric, behavioral, and psychosocial outcomes in offspring: a Swedish population-based register study2024
  2. 2Psychiatric Diagnoses in Parents and Psychiatric, Behavioral, and Psychosocial Outcomes in Their Offspring: A Swedish Population-Based Register Study2024 · 13 citations
  3. 3Association between parental psychiatric conditions and offspring psychiatric, behavioral, and psychosocial outcomes: A Swedish population-based children-of-monozygotic twins study2025 · 1 citations
  4. 4Association between parental ADHD and adverse offspring outcomes: Evidence from a nationwide Swedish register-based study2026
  5. 5Parental psychiatric diagnoses as predictive factors for autism spectrum disorder in the child: confluence of genetics and environment2024 · 1 citations