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October 23, 2025PLoS MedicineOpen Access

Association between parental psychiatric conditions and offspring psychiatric, behavioral, and psychosocial outcomes: A Swedish population-based children-of-monozygotic twins study

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Authors

MZMengping ZhouPeking University HLHenrik LarssonBroad Institute BDBrian M. D’OnofrioPDK International

Discussion

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Implication

Observational analysis showed significant psychiatric and behavioral problems in offspring with parental psychiatric diagnosis, suggesting environmental and genetic factors play a role.

Key Points

Offspring with parental psychiatric conditions showed higher rates of behavioral outcomes and psychosocial problems, indicating a troubling link.
Hazard ratios for time-to-event outcomes ranged from 1.34 to 2.53, suggesting significant risks linked to parental psychiatric diagnosis.
Analysis employed logistic regression and stratified Cox regression to address time-to-event outcomes among offspring of monozygotic twins.
Findings highlight the relevance of both environmental and genetic factors in understanding intergenerational psychiatric vulnerability.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68f9d6583f3788722249257c https://doi.org/10.1371/journal.pmed.1004784

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Implication

Observational analysis showed significant psychiatric and behavioral problems in offspring with parental psychiatric diagnosis, suggesting environmental and genetic factors play a role.

Association between parental psychiatric conditions and offspring psychiatric, behavioral, and psychosocial outcomes: A Swedish population-based children-of-monozygotic twins study

Discussion

Member takes

Implication

Key Points

Cite This Study

Association between parental psychiatric conditions and offspring psychiatric, behavioral, and psychosocial outcomes: A Swedish population-based children-of-monozygotic twins study

Discussion

Member takes

Implication

Key Points

Cite This Study

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