Experimental Investigation on Efficacy of Eudragit RS 100 Polymer in Prolonging Glibenclamide Release by Intragastric Floating Microsphere Formulation and Physicochemical Evaluation
In vitro experimental study demonstrates sustained intragastric release of glibenclamide, highlighting enhanced drug delivery for diabetes management.
Key Points
Intragastric floating microspheres prepared with Eudragit RS 100 effectively sustained glibenclamide release, achieving prolonged gastric retention and high drug entrapment.
Entrapment efficiency reached 93.19% with stable in-vitro buoyancy lasting up to 7 hours, confirming the robustness of the optimized floating microsphere formulation.
Solvent evaporation method produced porous floating microspheres, which may enhance oral glibenclamide bioavailability and reduce dosing frequency in diabetes management.