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September 16, 2025Journal of Applied Pharmaceutical ResearchOpen Access

Formulation, designing and evaluation of gastro-retentive floating microspheres using silymarin, curcumin and piperine for hepatoprotection

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Authors

MBMisbah Sultana Abdul Kausar BadewaleVTVarsha Tegeli

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Overview

Floating microspheres enhance drug absorption and improve bioavailability in liver protection treatments.

Key Points

  • The formulation achieved over 98% encapsulation efficiency and maintained buoyancy for 8 hours.
  • Cumulative drug release was 66.24% for curcumin, 68.21% for silymarin, and 72.82% for piperine after 12 hours.
  • The solvent evaporation technique was used to create the floating microspheres, ensuring a sustained release profile.
  • The microspheres demonstrated stability for 90 days under controlled conditions, supporting their therapeutic potential.

Cite This Study

Badewale et al. (2025) studied this question.

synapsesocial.com/papers/68d4539531b076d99fa5935ahttps://doi.org/10.69857/joapr.v13i4.1167
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bioavailability Enhancement of Curcumin by PEG-Based Gastroretentive System: Development and In Vitro Evaluation2025 · 2 citations
  2. 2Formulation and Evaluation of Floating Microspheres2024 · 3 citations
  3. 3"Development of Hollow Floating Microspheres for Enhanced Bioavailability of Drugs with Narrow Absorption Window"2026
  4. 4Experimental Investigation on Efficacy of Eudragit RS 100 Polymer in Prolonging Glibenclamide Release by Intragastric Floating Microsphere Formulation and Physicochemical Evaluation2024 · 4 citations
  5. 5Optimize bioavailability of silyamrin nanoparticles using Eudragit-pluronic F-68 combination2025