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September 12, 2025PharmaceuticsOpen Access

Bioavailability Enhancement of Curcumin by PEG-Based Gastroretentive System: Development and In Vitro Evaluation

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Authors

OCOrsolya CsendesGVGábor VasváriÁHÁdám Haimhoffer

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Overview

In Vitro evaluation shows improved bioavailability and promising cytotoxic profile for curcumin, indicating the system's potential in BCS class IV drug delivery.

Key Points

  • A novel gastroretentive system improved the bioavailability of curcumin, demonstrating effective drug delivery.
  • Using dynamic light scattering, the formulation exhibited beneficial properties, enhancing drug retention in the stomach.
  • The developed self-emulsifying system showed reduced cytotoxicity in Caco-2 cells while enhancing transcellular transport.
  • Assessment through various techniques confirmed the formulation's stability and extended release capabilities.

Cite This Study

Csendes et al. (2025) studied this question.

synapsesocial.com/papers/68d44f7331b076d99fa568cbhttps://doi.org/10.3390/pharmaceutics17091166
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In-Vitro Dynamic Bioaccessibility and Bioavailability as Key Parameters for Rational Engineering of Novel Curcumin Delivery Systems2025
  2. 2Formulation, designing and evaluation of gastro-retentive floating microspheres using silymarin, curcumin and piperine for hepatoprotection2025
  3. 3Design and development of gastro-retentive gel forming system comprising curcumin loaded Nanostructured lipid carrier for stomach specific delivery2024 · 1 citations
  4. 4Formulation, Development and In-vitro Characterization of Modified Release Tablets of Curcumin2024
  5. 5Enhancement of curcumin's physicochemical properties by developing its eutectic mixtures2024 · 1 citations