March 28, 2024Journal of Cancer Research and Clinical OncologyOpen Access

Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway

View Full Paper

Ask AI

Bookmark

Authors

CZChao ZhangHeilongjiang Academy of Sciences PQPeng QianSoochow University YTYuhang TangNanjing University of Chinese Medicine

Discussion

Member takes

Implication

In vitro study reveals resveratrol reduces glioblastoma growth and neuroinflammation via JAK2/STAT3 and NLRP3 inhibition, highlighting potential therapeutic targets for brain tumors.

Key Points

Resveratrol significantly reduces glioblastoma cell viability and invasive migration, while driving apoptosis and calming inflammatory signaling in the tumor microenvironment.
In LN-229 and U87-MG glioblastoma cell lines, resveratrol suppressed NLRP3 inflammasome activation, an inhibitory effect partially reversed by the addition of JAK/STAT agonist RO8191.
Cellular assays and Western blot revealed that resveratrol blocks the JAK2/STAT3 pathway, presenting a therapeutic strategy, though in vitro cell models require in vivo validation.

Cite This Study

Zhang et al. (2024) studied this question.

synapsesocial.com/papers/68e71ec4b6db643587698198 https://doi.org/10.1007/s00432-024-05625-5

View Full Paper

Ask AI

Bookmark

Implication

In vitro study reveals resveratrol reduces glioblastoma growth and neuroinflammation via JAK2/STAT3 and NLRP3 inhibition, highlighting potential therapeutic targets for brain tumors.

Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway

Discussion

Member takes

Implication

Key Points

Cite This Study

Resveratrol ameliorates glioblastoma inflammatory response by reducing NLRP3 inflammasome activation through inhibition of the JAK2/STAT3 pathway

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider