Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 18, 2026Biochemistry and Biophysics ReportsOpen Access

NF-κB signaling pathway mediates the anti-tumor effect of Ginsenoside Rg1 in glioblastoma

View Full Paper
Ask AI
Bookmark
Share

Authors

SLShuai LiJCJingjing ChangBCBo Chi

Discussion

Loading...

Member takes

Overview

Demonstrates Ginsenoside Rg1's anti-tumor effects in glioblastoma, indicating potential therapeutic applications.

Key Points

  • To investigate the anti-tumor effects of Ginsenoside Rg1 on glioblastoma cells and its underlying mechanisms.
  • Examined the effects of Ginsenoside Rg1 on U87-MG and U251-MG glioblastoma cells.
  • Measured cell viability and proliferation using MTT and BrdU assays.
  • Quantified NF-κB phosphorylation and transcription of genes via QRT-PCR and ELISA assays.
  • Analyzed caspase-3 and caspase-9 activity and the Bax/Bcl-2 ratio.
  • Ginsenoside Rg1 significantly decreased cell viability and proliferation.
  • Ginsenoside Rg1 enhanced caspase-3 and caspase-9 activity, promoting apoptosis.
  • Reduced phosphorylation of NF-κB and decreased IKK2 expression were observed.
  • Downregulation of invasion-related genes such as MMP-2 and MMP-9 occurred.
  • Ginsenoside Rg1 altered expression of NEMO, STAT3, and NHE1, indicating signaling modulation.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69ba42cf4e9516ffd37a35afhttps://doi.org/10.1016/j.bbrep.2026.102548
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting NF-κB signaling cascades of glioblastoma by a natural benzophenone, garcinol, via in vitro and molecular docking approaches2024 · 4 citations
  2. 2Ginsenoside-Rh2 inhibits U251 glioma cell migration and invasion via the Gab2/Akt2 pathway2026
  3. 3Ginsenoside Rg1 Induces Apoptotic Cell Death in Triple‐Negative Breast Cancer Cell Lines and Prevents Carcinogen‐Induced Breast Tumorigenesis in Sprague Dawley Rats2020 · 26 citations
  4. 4Ginsenoside Rg1 inhibits multiple myeloma and overcomes bortezomib resistance through AMPK-mTOR pathway2024 · 1 citations
  5. 5Ginsenoside Rg1 Suppresses Pyroptosis via the NF-κB/NLRP3/GSDMD Pathway to Alleviate Chronic Atrophic Gastritis <i>In Vitro</i> and <i>In Vivo</i>2024 · 8 citations