The iPhylo Suite: An Interactive Platform for Building and Annotating Biological and Chemical Taxonomic Trees

Accurate and rapid taxonomic classifications are essential for systematically exploring organisms and metabolites in diverse environments. Many tools have been developed for biological taxonomic trees, but limitations apply, and a streamlined method for constructing chemical taxonomic trees is lacking. We present the iPhylo suite ( https://www.iphylo.net/ ), a comprehensive, automated, and interactive platform for biological and chemical taxonomic analysis. The iPhylo suite includes the Tree and Visual web-based modules for interactive building and annotating biological and chemical taxonomic trees, and a stand- alone command-line interface (CLI) module for local use and deployment on high-performance computing clusters. Furthermore, the iPhylo visualization module is fully implemented in R, allowing users to save progress locally and modify the underlying R codes. Finally, the iPhylo CLI module extends the analysis to all hierarchical relational databases. In summary, the iPhylo suite provides an integrated interactive framework for in-depth taxonomic analyses of biological and chemical features and beyond. Highlights A platform for both biological and chemical classification analysis and visualizations. A stand-alone Command line interface module for local or HPC deployment. R-based interactive visualization module with session-saving options. Supports customized hierarchical databases for analysis beyond taxonomy.