Experimental study reveals that TRPM5 channel activation requires coordinated PKC phosphorylation and calcium elevation, indicating potential targets for metabolic disease therapies.
Key Points
TRPM5 channel activation requires both intracellular calcium elevation and PKC phosphorylation to evoke monovalent currents at physiological membrane potentials.
Electrophysiological analysis indicates that physiological calcium concentrations alone activate TRPM5 channels exclusively at positive voltages rather than resting states.
Regulation of PKC phosphorylation may offer a viable therapeutic pathway for modulating TRPM5 channel activity in metabolic disorders—in vitro model; further preclinical work needed.