Indoxyl sulfate is a protein binding urotoxin, which is discharged by the kidney through secreted in proximal tubule and accumulates in patients with renal failure, It can cause the endothelial dysfunction and cardiovascular disease. Due to has a high affinity for albumin, cannot effectively remove by hemodialysis and hemodiafiltration. Therefore, protein-bound urinary toxins have become a focus of renal replacement treatment.We used high flux dialysis combined with hemoperfusion for treatment, and found that the clearance of indoxyl sulfate was higher than high flux dialysis and hemodiafiltration, and 4 hours was better than 2 hours.
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Liu et al. (2024) studied this question.
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