March 26, 2024CureusOpen Access

Comparison of Glycated Hemoglobin (HbA1c) Values Estimated by High-Performance Liquid Chromatography and Spectrophotometry: A Pilot Study

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Authors

ARAvik RayBrigham and Women's Hospital SAShubham AtalAll India Institute of Medical Sciences Bhopal SSSwati SharmaBanasthali University

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Implication

Cross-sectional study reveals strong correlation between spectrophotometric and chromatographic HbA1c in patient blood samples, highlighting potential for portable monitoring.

Key Points

Spectrophotometric estimation of glycated hemoglobin correlates strongly with high-performance liquid chromatography, demonstrating viable concordance across clinical blood samples.
Pearson correlation coefficient was 0.65 between spectrophotometry and high-performance liquid chromatography, supported by linear regression analysis yielding p < 0.001.
Cross-sectional testing of venous blood samples supports spectrophotometry as an alternative for HbA1c estimation, though larger well-powered studies are needed for validation.

Cite This Study

Ray et al. (2024) studied this question.

synapsesocial.com/papers/68e7254ab6db64358769f1a3 https://doi.org/10.7759/cureus.56964

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Implication

Cross-sectional study reveals strong correlation between spectrophotometric and chromatographic HbA1c in patient blood samples, highlighting potential for portable monitoring.

Comparison of Glycated Hemoglobin (HbA1c) Values Estimated by High-Performance Liquid Chromatography and Spectrophotometry: A Pilot Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparison of Glycated Hemoglobin (HbA1c) Values Estimated by High-Performance Liquid Chromatography and Spectrophotometry: A Pilot Study

Discussion

Member takes

Implication

Key Points

Cite This Study

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