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March 25, 2024Aging Pathobiology and TherapeuticsOpen Access

Exploring the complex interplay between anxiety, aging, and behavior in CB6F1 and C57BL/6 mice: Implications for cognitive function

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Authors

KLKunyuan LiGLGerald Yu LiaoAKAddison Keely

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Overview

Behavioral assessment demonstrates increased anxiety in aging male mice, suggesting anxiety operates independently of cognitive function while reducing voluntary physical activity.

Key Points

  • Anxiety in novel environments increases with age as shown by peripheral preference in an open-field test, yet it does not diminish cognitive performance in aging mice.
  • Elevated anxiety levels correlate negatively with distance covered during voluntary wheel running, whereas no associations emerge with grip strength or rotarod performance.
  • Behavioral assessment across aging male mice tracks motor and cognitive phenotypes, highlighting anxiety management as a potential target to improve healthy aging outcomes.

Cite This Study

Li et al. (2024) studied this question.

synapsesocial.com/papers/68e7275eb6db6435876a0f71https://doi.org/10.31491/apt.2024.03.133
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Age-Related Decline and Behavioral Validity in C57BL/6 and CB6F1 Mice2024 · 1 citations
  2. 2Enhanced excitatory synaptic transmission onto glutamatergic neurons in the basolateral amygdala may drive aging-related elevation in innate anxiety-like behaviors in male mice.2026
  3. 3BK channel overactivity in NAc core D1R-expressing neurons elevates anxiety with age in mice2026
  4. 4Home-Cage Monitoring Methods Reveal Age- and Strain-Related Differences in Motor, Thermal, and Cognitive Functions in Male Mice of Two Inbred Strains2026
  5. 5Neuropsychological Correlates of Anxiety in Older Adults: A Cross-Sectional Comparison with Controls Without a Psychiatric Diagnosis2026