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April 17, 2026Journal of Neuroscience MethodsOpen Access

Home-Cage Monitoring Methods Reveal Age- and Strain-Related Differences in Motor, Thermal, and Cognitive Functions in Male Mice of Two Inbred Strains

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Authors

MFMahvish FaisalUniversity of TartuKRKonstantin RadyushkinJBJan BaumgartJohannes Gutenberg University Mainz

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Overview

Automated home-cage monitoring uncovers behavioral differences in aging male mice across inbred strains, suggesting a need for more reliable assessments.

Key Points

  • This research aims to understand how aging and genetic background influence motor, thermal, and cognitive functions in male mice.
  • Utilized advanced RFID-based automated home-cage platforms (Mouse Matrix and IntelliCage) for monitoring
  • Compared two inbred strains: C57BL/6 J and 129S2/SvPasCrl
  • Measured circadian locomotor activity, core body temperature, and cognitive performance
  • Conducted assessments in a familiar home-cage environment to reduce stress
  • Aged mice exhibited reduced locomotor activity and impaired anticipatory behavior
  • Significant differences in anxiety and adaptability between strains, with 129S2/SvPasCrl showing higher anxiety
  • C57BL/6 J mice demonstrated greater cognitive flexibility and quicker learning
  • Found differences in thermal rhythms, with 129S2/SvPasCrl displaying higher thermal stability

Cite This Study

Faisal et al. (2026) studied this question.

synapsesocial.com/papers/69e1cdc45cdc762e9d857166https://doi.org/10.1016/j.jneumeth.2026.110773
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