FIGURE 3 from Identification of Nonfunctional Alternatively Spliced Isoforms of STING in Human Acute Myeloid Leukemia

Identification of STING germline and transcript variants in AML. A, Summary of sequencing results indicating identification of known STING variant alleles and novel spliced isoforms. B, Structure of STING genomic locus and annotated coding sequence maps for WT, STING-I3R, and STING-Ex4D. Identification and validation of STING-I3R allele in primary bone marrow aspirates (C) and in normal donors (D) using primers to selectively amplify WT or I3R STING alleles.