The Assessment of Ferulic Acid in Rats with Vincristine-Induced Neuropathy

The main goal of the current investigation was to find out how ferulic acid (FA) affected the neuropathic pain that vincristine caused in rats. Rats were given vincristine to cause painful neuropathy. To measure the mechanical dynamic allodynia, cold allodynia, degree of mechanical hyperalgesia, heat hyperalgesia, and muscle relaxant rota rod, respectively. Several pain-sensitive tests, including the von frey hair test, pinprick, hot plate, and rota rod, were carried out on various weeks (0, 4 and 8 weeks) as indicators of inflammation and oxidative stress the IL-1β, IL-10, tumour necrosis factor-alpha (TNF-α), tissue parameters like Na+/K+ ATPase, Ca2+ ATPase & Mg2+ ATPase and superoxide dismutase (SOD), catalase (CAT) level, reduced glutathione (GSH), lipid peroxidase (LPO), NO level were assessed. Gabapentin (30 mg/kg i.p.) in addition to FA (50, 100, as well as 150 mg/kg orally) was given for 08 weeks. FA administration markedly decreased vincristine-induced behavioral and biochemical alterations (p < 0.05). FA also reduced the inflammation IL-10 and increased IL-1β and TNF-α. FA also reduces oxidative stress (LPO, NO level) and increases at (GSH, SOD, CAT levels) that vincristine caused. FA can alleviate the painful states brought on by vincristine-induced painful neuropathy, which might also be explained by its anti-inflammatory effects and following reduction of oxidative stress.