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March 24, 2024Chemical and Pharmaceutical BulletinOpen Access

Synthesis of 2-Substituted Indoles via Migration Reaction of 3-Substituted Indoles with Triflic Acid

Kosuke Nakashima Yuka Kudo Yasuyuki Matsushima Shin‐ichi Hirashima Tsuyoshi Miura

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Abstract

This study showcases the 1,2-migration reactions of alkyl and aryl groups on the indole molecule. Trifluoromethanesulfonic acid effectively facilitates the migration of the substituent from C3- to C2-position of the indole structure. The resulting C2-substituted indoles offer a valuable pathway for the synthesis of natural products and medicinal compounds.

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Cite This Study

Nakashima et al. (2024) studied this question.

synapsesocial.com/papers/68e72962b6db6435876a32ab https://doi.org/10.1248/cpb.c23-00792

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