Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025The Journal of Organic Chemistry

Synthesis of 2-Trifluoromethylindolines via Rh(III)-Catalyzed Chelation-Assisted C–H Bond Activation and Annulation of Anilines with CF3-Imidoyl Sulfoxonium Ylides

View Full Paper
Ask AI
Bookmark
Share

Authors

PLPinyi LiJCJian ChenZYZuguang Yang

Discussion

Loading...

Member takes

Overview

Method demonstrates the formation of trifluoromethylindolines from anilines, suggesting new pathways for synthesizing complex molecules.

Key Points

  • The protocol yielded a variety of 2-trifluoromethylindolines, demonstrating efficient synthesis of complex carbon structures.
  • Rh(III)-catalysis enabled a unique cascade involving C-H bond activation and intramolecular nucleophilic addition processes.
  • The reaction utilized CF3-imidoyl sulfoxonium ylides, which effectively contributed to the formation of biologically important scaffolds.
  • This method could be scaled up to 2 mmol, highlighting its practicality for synthetic applications in organic chemistry.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68c1d21f54b1d3bfb60f756ahttps://doi.org/10.1021/acs.joc.5c01490
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Synthesis of 2-(α-trifluoromethylamino)indoles <i>via</i> stepwise cascade transformation of imidoyl sulfoxonium ylides with <i>ortho</i> -chloromethyl anilines2026
  2. 2Rhodium‐Catalyzed Cascade Annulation of <i>N</i> ‐Nitrosoanilines With Trifluoromethyl‐Imidoyl Sulfoxonium Ylides for the Synthesis of Trifluoromethyl‐Functionalized Indazole <i>N</i> ‐Oxides2026 · 2 citations
  3. 3Synthesis of Fluorinated Spiroindolenines by Transition Metal-Catalyzed Indole Dearomatizations2024 · 1 citations
  4. 4Recent Advancements in Trifluoromethylation Strategies for Indoles, Oxindoles and Indolines2024 · 6 citations
  5. 5Synthesis of Fluorinated Spiroindolenines by Transition Metal‐Catalyzed Indole Dearomatizations2024 · 8 citations