Chemo-and Stereoselective Rh(III)-Catalyzed Coupling of Indoles with CF3 -Imidoyl Sulfoxonium Ylides via Thioamide-directed C-H Activation

Hongliang Wu; Ruirui Zhai; Liming Zhou; Siyu Chang; Guiwei Yao; Chen Li (54018); Fengjuan Chen; Dulin Kong; Xun Chen

doi:10.1039/d6qo00532b

January 1, 2026Organic Chemistry Frontiers

Chemo-and Stereoselective Rh(III)-Catalyzed Coupling of Indoles with CF3 -Imidoyl Sulfoxonium Ylides via Thioamide-directed C-H Activation

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Key Points

This research aims to develop a method for the selective coupling of indoles using Rh(III) catalysis.
Thioamide-directed C-H activation
Utilization of CF3-imidoyl sulfoxonium ylides
Investigation of effects by additives, solvents, and temperature
Demonstrated switchable synthesis based on reaction conditions
Achieved high levels of chemoselectivity during coupling reactions
Outlined the critical role of additives and solvent choices in directing the reaction outcome

Implication

Divergent coupling of indoles with CF3-imidoyl sulfoxonium ylides illustrates thioamide-mediated C-H activation, enabling versatile synthesis.

Abstract

A thioamide-directed, Rh(III)-catalyzed divergent coupling of indoles with CF3-imidoyl sulfoxonium ylides is developed. The chemoselectivity of this transformation is critically modulated by additives, solvents, and temperature, enabling the switchable synthesis...

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Cite This Study

Wu et al. (2026) studied this question.

synapsesocial.com/papers/6a2a52ae80c8f91e7f39e8f4 https://doi.org/10.1039/d6qo00532b

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Chemo-and Stereoselective Rh(III)-Catalyzed Coupling of Indoles with CF3 -Imidoyl Sulfoxonium Ylides via Thioamide-directed C-H Activation

Key Points

Implication

Abstract

Discussion

Cite This Study

Chemo-and Stereoselective Rh(III)-Catalyzed Coupling of Indoles with CF3 -Imidoyl Sulfoxonium Ylides via Thioamide-directed C-H Activation

Key Points

Implication

Abstract

Discussion

Cite This Study

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