Ir(III)-Catalyzed Selective C-H Acylmethylation and Dicarbonylation of Indolizines with β-Ketosulfoxonium Ylides

Shang‐Shi Zhang; Zifeng Yang; Yuan-Jie Meng; Xinxing Liu; Jiaohang Wei; Wen-Rong Wu; Xiang Liu; Pengju Feng

doi:10.1039/d5cc04380h

January 1, 2025Chemical Communications

Ir(III)-Catalyzed Selective C-H Acylmethylation and Dicarbonylation of Indolizines with β-Ketosulfoxonium Ylides

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Key Points

The Ir(III)-catalyzed process enables efficient synthesis of C3-functionalized indolizines with high regioselectivity.
The reaction conditions can be modified to control the acylmethylation and dicarbonylation outcomes effectively.
This approach provides a pathway for the synthesis of complex indolizine derivatives with diverse functional groups.
The method showcases the versatility of β-ketosulfoxonium ylides in facilitating selective functionalization of indolizines.

Implication

The study reports Ir(III)-catalyzed C-H acylmethylation and dicarbonylation of indolizines, suggesting efficient synthesis of C3-functionalized derivatives.

Abstract

Herein, we report an Ir(III)-catalyzed regioselective C-H acylmethylation of indolizines with β-ketosulfoxonium ylides, enabling the efficient synthesis of C3-functionalized indolizine derivatives. By modifying the reaction conditions, a controllable Ir(III)-catalyzed dicarbonylation...

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Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c192659b7b07f3a06173b4 https://doi.org/10.1039/d5cc04380h

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Ir(III)-Catalyzed Selective C-H Acylmethylation and Dicarbonylation of Indolizines with β-Ketosulfoxonium Ylides

Key Points

Implication

Abstract

Discussion

Cite This Study

Ir(III)-Catalyzed Selective C-H Acylmethylation and Dicarbonylation of Indolizines with β-Ketosulfoxonium Ylides

Key Points

Implication

Abstract

Discussion

Cite This Study

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