Synthesis of 2-(α-trifluoromethylamino)indoles via stepwise cascade transformation of imidoyl sulfoxonium ylides with ortho -chloromethyl anilines

Yang Pan; Wang Yin; Xin Zhou; Tengxiaoxiao Liu; Xiaoke Zhang; Tao Jiang

doi:10.1039/d6ra01734g

January 1, 2026RSC AdvancesOpen Access

Synthesis of 2-(α-trifluoromethylamino)indoles via stepwise cascade transformation of imidoyl sulfoxonium ylides with ortho -chloromethyl anilines

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Key Points

The aim is to create an efficient method for synthesizing 2-(α-trifluoromethylamino)indole scaffolds.
Developed a one-pot synthesis technique
Utilized CF3-imidoyl sulfoxonium ylides
Incorporated ortho-chloromethyl anilines
Successfully synthesized 2-(α-trifluoromethylamino)indoles efficiently in one step

Implication

One-pot method synthesizes 2-(α-trifluoromethylamino)indoles from two reagents, indicating practical application.

Abstract

We have developed an efficient one-pot method for the synthesis of 2-(α-trifluoromethylamino)indole scaffolds from CF 3 -imidoyl sulfoxonium ylides and ortho -chloromethyl anilines.

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Cite This Study

Pan et al. (2026) studied this question.

synapsesocial.com/papers/6a0021cdc8f74e3340f9cc93 https://doi.org/10.1039/d6ra01734g

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Synthesis of 2-(α-trifluoromethylamino)indoles via stepwise cascade transformation of imidoyl sulfoxonium ylides with ortho -chloromethyl anilines

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis of 2-(α-trifluoromethylamino)indoles via stepwise cascade transformation of imidoyl sulfoxonium ylides with ortho -chloromethyl anilines

Key Points

Implication

Abstract

Discussion

Cite This Study

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