What question did this study set out to answer?

The aim is to create an efficient method for synthesizing 2-(α-trifluoromethylamino)indole scaffolds.

May 10, 2026RSC Advances0 citationsOpen Access

Synthesis of 2-(α-trifluoromethylamino)indoles via stepwise cascade transformation of imidoyl sulfoxonium ylides with ortho -chloromethyl anilines

YPYang PanGuiyang University WYWang YinZunyi Medical University XZXin ZhouZunyi Medical University

Key Points

The aim is to create an efficient method for synthesizing 2-(α-trifluoromethylamino)indole scaffolds.
Developed a one-pot synthesis technique
Utilized CF3-imidoyl sulfoxonium ylides
Incorporated ortho-chloromethyl anilines
Successfully synthesized 2-(α-trifluoromethylamino)indoles efficiently in one step

Abstract

We have developed an efficient one-pot method for the synthesis of 2-(α-trifluoromethylamino)indole scaffolds from CF 3 -imidoyl sulfoxonium ylides and ortho -chloromethyl anilines.

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Cite This Study

Pan et al. (Thu,) studied this question.

synapsesocial.com/papers/6a0021cdc8f74e3340f9cc93 https://doi.org/https://doi.org/10.1039/d6ra01734g

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