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March 22, 2024Cancer Research

Abstract 5603: Defining the functions of the BRCA2 BRC repeats in modulating RAD51 binding and activity

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Authors

JJJulia R. JensenYale UniversityRJRyan B. JensenYale University

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Jensen et al. (2024) studied this question.

synapsesocial.com/papers/68e72e1db6db6435876a7319https://doi.org/10.1158/1538-7445.am2024-5603
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unveiling the molecular mechanism of BRCA2-RAD51 interaction to tackle cancer onset2023
  2. 2Abstract 1850 The Association between Tumor Suppressor BRCA2 and DNA in Maintaining Genome Integrity2024
  3. 3DMC1 and RAD51 bind FxxA and FxPP motifs of BRCA2 via two separate interfaces2024 · 13 citations
  4. 4Abstract 1187 A novel activity of the RAD52 protein that is essential for the viability of BRCA-deficient breast and ovarian cancer cells2024
  5. 5BRCA2 C-terminal clamp restructures RAD51 dimers to bind B-DNA for replication fork stability2024