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March 22, 2024Cancer Research

Arsenic Exposure Induces Malignant Transformation in Bladder Cancer Models

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Authors

BTBhawna TyagiMVMohit VashishtaNTNeha Tyagi

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Overview

Preclinical analysis shows arsenic's role in malignant transformation of bladder, suggesting critical stem cell activation.

Key Points

  • Malignant transformation occurs in bladder cells after arsenic exposure, activating critical stemness traits.
  • ALDH1A1 activation increased 50,000-fold in arsenic-exposed cells, indicating significant cellular changes.
  • Preclinical models demonstrated bladder hyperplasia and cancer following exposure to arsenic levels up to 30 PPM over six months.  Moreover, xenografted models showed tumor formation from arsenic-transformed cells, providing insight into cancer progression.

Cite This Study

Tyagi et al. (2024) studied this question.

synapsesocial.com/papers/68e72e37b6db6435876a7f72https://doi.org/10.1158/1538-7445.am2024-1473
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 2151: Understanding the mechanisms by which environmental arsenic elevates the risk of urothelial bladder cancer.2026
  2. 2Integrated analyses of the microbiome, metabolome, and spatial transcriptomics reveal sex-dependent bladder vulnerability to chronic inorganic arsenic2026
  3. 3Abstract 6140: Gene-environment interactions for lifetime water arsenic exposure and bladder cancer risk in the New England Bladder Cancer study2024
  4. 4Abstract 7649: Urinary arsenic speciation and metabolic indices associate with exposure chemistry and prostate cancer aggressiveness.2026
  5. 5Abstract 3373: Metabolism and carcinogenic potential of inorganic arsenic in humanized-liver mice2026