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April 5, 2026Cancer Research

Abstract 2151: Understanding the mechanisms by which environmental arsenic elevates the risk of urothelial bladder cancer.

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Authors

YHYuyang HuangBGBritton C. GoodaleJMJordan E. Magurk

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Overview

This research identifies how arsenic exposure impacts urothelial differentiation, increasing bladder cancer risk in zebrafish and human cells.

Key Points

  • This study aims to understand how environmental arsenic affects bladder urothelium and increases the risk of urothelial bladder cancer.
  • Used adult zebrafish and human cell lines to assess effects of arsenic exposure.
  • Conducted a 28-day arsenic exposure with dosages of 500 ppb As (III).
  • Performed bulk and single-cell RNA sequencing to evaluate gene expression changes.
  • Analyzed changes in urothelial differentiation markers in response to arsenic.
  • Histological evidence of bladder hyperplasia and thickening was observed in zebrafish after arsenic exposure.
  • Cancer-related pathways such as MYC and mTOR were upregulated in arsenic-exposed zebrafish bladders.
  • A shift from UPK+ to UPK- phenotype was seen in urothelial cells, indicating loss of differentiation.
  • In human cell lines, dose-dependent decrease in differentiation markers was confirmed following arsenic exposure.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69d1fceba79560c99a0a2ad1https://doi.org/10.1158/1538-7445.am2026-2151
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