• Primary peritoneal clear cell carcinoma can arise from endometriotic implants within the abdomen and pelvis. • Immunohistochemistry can be used to confirm primary disease site. Endometriotic origin can be inferred based on clinical history and intraoperative findings suggestive of endometriosis. • While no standardized treatment exists, consideration should be given to cytoreductive surgery with adjuvant chemotherapy. Adjuvant radiation can also be considered for local control.
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Harris et al. (2024) studied this question.
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